The Most Significant Change Handbook provides an overview of the approach in response to the need for enhancing the availability of more compelling stories and best practices from the Centre’s grassroots level of interventions, complementing its results-based management approach. It clarifies the development of the MSC approach, followed by an outline of the main advantages and disadvantages of the approach. Examples are then provided to illustrate how the approach has been applied in different contexts and organizations. It also provides guidelines for applying the approach to KAICIID interventions. The Annexes provide a bibliography of the main sources of information used and some MSC practical tools for managers and staff.